National Chung Hsing University, Taiwan
Title: The novel and significant roles played by cyclic-di-gmp in controlling a wide variety of bacterial physiology
Biography: Shan-Ho Chou
The discovery of c-di-GMP second messenger is one of the most important breakthroughs in the microbial world in the past two decades. This molecule is present in most bacteria, regulating a plethora variety of important bacterial activities such as biofilm formation, biogenesis and function of flagella and pili, cell differentiation, and biosynthesis of natural product and secretion of pathogenic factors, through binding to an unprecedented array of effectors. There are usually tens or even hundreds of enzymes that make or break c-di-GMP in every bacterial genome. These enzymes usually carry extra domains to activate their activities for responding to environmental changes. Many c-di-GMP biosynthesis (diguanlyate synthetase) or degradation (phosphodiesterase) enzymes have been elucidated. However, only a few c-di-GMP receptors have been characterized to date. To get a better understanding of how c-di-GMP carries out its diverse functions, it is of crucial importance to decipher the possible c-di-GMP binding motifs.